A recent study indicates that individuals who come off popular slimming jabs like Wegovy and Mounjaro may regain lost weight much more quickly than those who end conventional diet and exercise programs.
Findings released in a major medical journal demonstrates that while overweight people frequently drop about a fifth of their total mass while on the medication, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People using such treatments should be aware of the danger of rapid rebound weight gain when the treatment concludes," cautioned lead investigator Dr. Susan Jebb.
This pace of regain implies a reversion to starting weight in about one and a half years.
Comparing Treatments
The study, which reviewed dozens of studies involving thousands of participants, compared the effects of the injectable medications with older methods.
The team point out that people who lose weight through dieting generally have a slower creep back—approximately 100 grams monthly—post-intervention.
Understanding the Fast Rebound
Doctors believe the mechanism of the jabs accounts for the accelerated rebound.
These medications copy a natural hormone called GLP-1, which moderates appetite.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and may also reduce sensitivity to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this hormone supplement results in appetite is uncontrolled, making binge eating a significant risk."
A Chronic Condition?
The NHS recommend the jabs for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians argue that, considering the high risk of relapse, the treatment should be considered life-long.
This opinion is supported by pharmaceutical companies, who note that the findings "emphasize the chronic character of obesity," similar to managing diseases like high blood pressure.
Patient Testimonies
Individuals who have stopped the jabs describe a intense return of hunger.
"I experienced a switch activating and you're instantly starving," described one woman.
This challenge is exacerbated if users have not adopted permanent lifestyle or habit modifications during treatment.
Widespread Adoption
Figures suggest that millions of people in the UK have used these injections in the last 12 months, with demand continuing to grow.
- Adoption is more common among females than men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Finally, clinicians emphasize that while the jabs are effective agents for shedding pounds, they are not a permanent fix and long-term success likely depends on ongoing behavioural management.
